Adipose tissue signatures related to weight changes in response to calorie restriction and subsequent weight maintenance using lipidome and gene profiling network analysis
نویسندگان
چکیده
Maintenance of weight loss remains an obstacle in successful treatment of obese individuals. The long term impact of calorie restriction on adipose tissue biology is poorly characterized. Molecular and lipid markers of these processes may provide wider understanding in the mechanisms underlying weight control. We aimed at identifying relevant relationship between clinical traits, clusters of genes and adipose tissue (AT) fatty acids (FAs) with respect to low calorie diet (LCD) and subsequent weight maintenance.
منابع مشابه
System Model Network for Adipose Tissue Signatures Related to Weight Changes in Response to Calorie Restriction and Subsequent Weight Maintenance
Nutrigenomics investigates relationships between nutrients and all genome-encoded molecular entities. This holistic approach requires systems biology to scrutinize the effects of diet on tissue biology. To decipher the adipose tissue (AT) response to diet induced weight changes we focused on key molecular (lipids and transcripts) AT species during a longitudinal dietary intervention. To obtain ...
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